A Second World War surplus building purchased by Dickinson College in Carlisle, Pennsylvania in 1948 became the third South College in the college history.  To make the newest South College more suitable for academic purposes, the College dismantled and re-erected the building at a cost of $46,943.  John K. Bixler designed the new structure, which opened in June 1948. 

The new South College featured classrooms and faculty offices on the upper floors, with the lower level including a student lounge, which was later enhanced with a snack bar.  When the Holland Union Building was completed, the College converted this student common area into extra classrooms and offices for the mathematics department.  An indoor handball court also graced the building for years. In 1967 a portion of the building became the IBM computer center, the first such center in the College’s history, and a year later the center offered the College’s first computer science courses.  The mathematics and computer science departments occupied South College until moving into a new science building in 1999. Elements of computer services also moved from the building in 2003, taking offices in the basement of the Library after the creation of the combined Library and Information Services, while the mainframe, other hardware, and its support personnel remained in South College.