Amy Fisher was born in Harrisburg, Pennsylvania on December 29, 1872, the child of Daniel and Eva Brightbill Fisher.  She attended Carlisle High School and Dickinson Preparatory School before entering Dickinson College in 1891.  Graduating Phi Beta Kappa in 1895 with her class, she secured a master of arts degree in 1897.  During these two years, she also taught at the Preparatory School, having the distinction of being the first woman to do so. 

In 1897 she became assistant principal of the high school in Doylestown, Pennsylvania, retaining her position there until 1904.  She then returned to Carlisle, living at a house on the southwest corner of High and College Streets.  In 1932, she returned to employment at Dickinson College, becoming curator of the growing collection of Dickinsoniana. She held this position until her death. 

Amy Fisher died on April 6, 1938, having contracted a "fatal illness" during a two month South American cruise. She was sixty-five years old.